Redefining micrometastasis in prostate cancer - a comparison of circulating prostate cells, bone marrow disseminated tumor cells and micrometastasis: Implications in determining local or systemic treatment for biochemical failure after radical prostatectomy
نویسندگان
چکیده
منابع مشابه
Redefining micrometastasis in prostate cancer - a comparison of circulating prostate cells, bone marrow disseminated tumor cells and micrometastasis: Implications in determining local or systemic treatment for biochemical failure after radical prostatectomy.
The presence of cells positive for cytokeratins or prostate-specific antigen (PSA) in bone marrow aspirates (BMAs) has been used to indicate the presence of micrometastasis. The aim of this prospective study of prostate cancer patients was to determine the presence of prostate cells in blood and BMAs and to compare them with bone marrow biopsy touch prep samples. The results indicated that ther...
متن کاملCirculating tumor cells and bone marrow micrometastasis.
Sensitive immunocytochemical and molecular assays allow the detection of single circulating tumor cells (CTC) in the peripheral blood and disseminated tumor cells (DTC) in the bone marrow as a common and easily accessible homing organ for cells released by epithelial tumors of various origins. The results obtained thus far have provided direct evidence that tumor cell dissemination starts alrea...
متن کاملPSA Kinetics and Bone Marrow Micrometastasis to Define Relapse in Men after Radical Prostatectomy for Prostate Cancer
Biochemical failure (BF) after radical prostatectomy for prostate cancer, occurs in approximately 30% of patients. Although there have been cases described of BF of up to 10-15 years after surgery, it usually occurs within 12 months post surgery, with 95% occurring within the first five years (Pound et al., 1997; Han et al., 2003). Although different guidelines have defined biochemical failure ...
متن کاملSecondary Circulating Prostate Cells Predict Biochemical Failure in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Disease
INTRODUCTION Although 90% of prostate cancer is considered to be localized, 20%-30% of patients will experience biochemical failure (BF), defined as serum PSA >0.2 ng/mL, after radical prostatectomy (RP). The presence of circulating prostate cells (CPCs) in men without evidence of BF may be useful to predict patients at risk for BF. We describe the frequency of CPCs detected after RP, relation ...
متن کاملDisseminated tumor cells in prostate cancer patients after radical prostatectomy and without evidence of disease predicts biochemical recurrence.
PURPOSE Men with apparently localized prostate cancer often relapse years after radical prostatectomy. We sought to determine if epithelial-like cells identified from bone marrow in patients after radical prostatectomy, commonly called disseminated tumor cells (DTC), were associated with biochemical recurrence. EXPERIMENTAL DESIGN We obtained bone marrow aspirates from 569 men prior to radica...
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ژورنال
عنوان ژورنال: International Journal of Molecular Medicine
سال: 2012
ISSN: 1107-3756,1791-244X
DOI: 10.3892/ijmm.2012.1071